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Influence of the physico-chemical characteristics of chito-oligosaccharides (COS) on antioxidant activity
Inmaculada Mateos-Aparicio, Valérie Pollet, G. Gao, Frederic Michel, Luc Courard
Carbohydrate Polymers, 2013
Chito-oligosaccharides (COS) are being used as important functional materials for many applications due to their bioactivities. The aim of this research has been to assess the relationship between the physico-chemical characteristics, average molecular weight (Mw), acetylation degree (DA), polymerization degree (DP) and specially sequence composition determined by MALDI-TOF MS and the antioxidant properties of COS. These oligosaccharides were obtained by enzymatic depolymerization with chitosanase and lysozyme using a specific chitosan and its reacetylated product. The COS fraction below 5 kDa obtained from chitosanase depolymerization showed the highest capacity to scavenge DPPH radicals and to reduce Fe(3+). A correlation was found between the relative amount of molecules with a given A/D (acetylated vs deacetylated units) ratio within the COS and their antioxidant activity, which could be used to predict the antioxidant behavior of a fraction of chito-oligosaccharides.
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An Overview on Natural Polysaccharides with Antioxidant Properties
Current Medicinal Chemistry
Pharmacotherapy using natural substances can be currently regarded as a very promising future alternative to conventional therapy. With the rapid development of biotechnologies and analytical techniques, a great number of methods have been developed for the identification and quantification of the material, extracts, and products of natural ingredients. The advances available today. The need for safer drugs without side effects has led to the use of natural ingredients with proven safety. In recent years, some bioactive polysaccharides isolated from natural sources have attracted much attention in the field of biochemistry and pharmacology. As an example, polysaccharides or their glycoconjugates were shown to exhibit multiple biological activities including anticarcinogenic, anticoagulant, immunostimulating, antioxidant, etc. During the last several years, we have witnessed a steady expansion in the number of publications that focus in antioxidant polysaccharides. This review presents current findings on the latest advancements and trends in antioxidant polysaccharides isolated from the following: plants, fungi, bacteria, animal sources, and algae. Some interesting studies focus on investigation of the relationship between their structure and antioxidant activity, elucidation of their antioxidant mechanism at the molecular level, and improvement of their various biological activities by chemical modifications. Although the mechanism of their antioxidant action is still not completely clear, these polysaccharides are suggested to enhance cell-mediated immune responses in vivo and in vitro and act as biological response modifiers.
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Recent trends in chemical modification and antioxidant activities of plants-based polysaccharides: A review
Muhammad Muneeb Ahmad
Carbohydrate Polymer Technologies and Applications, 2021
The increasing consumption of plants-based polysaccharides in various industries is demanding to boost their structural and functional attributes. Functional attributes including the antioxidant behavior of plants-based polysaccharides are much important due to their meaningful transfer of value-added properties in different practical commodities. This review is aimed to attract the attention of researchers to boost the antioxidant activities of plants-based polysaccharides by using different chemical modification methods. In this review, different modification methods of plants-based polysaccharides were particularized to make ease to select the competent modification protocols and to analyze the resulted antioxidant potential of native and modified polysaccharides. The antioxidant activities of plants-based polysaccharides were increased significantly after chemical modification. These significant improvements in antioxidant activities of plants-based polysaccharides suggested to employ them in food, pharmaceutical and cosmetic products to improve their healthy life.
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A comparative study of antioxidative activities of cell-wall polysaccharides
Ivan Spasojevic
Carbohydrate Research, 2011
Oxidative burst in plants is elicited by biotic and abiotic stressors. Analogously to some monosaccharides which act as intracellular antioxidants, cell-wall polysaccharides may be in charge of buffering free-radical production in the extracellular compartment under pronounced prooxidative settings. Although a wide range of plant polysaccharides have been examined for their antioxidative properties, this usually has not been done in a coherent and comparative manner and against biologically relevant reactive species. Here we show that different cell-wall polysaccharides, cellulose, pectin, D-galacto-D-mannan, arabinogalactan, and xylan, exhibit distinctive antioxidative activities against the hydroxyl radical (·OH)-generating Fenton reaction and superoxide. We found, using an EPR spin-trapping method, that the main carriers of 'anti-Fenton' activity in the plant cell wall are pectin and xylan. They most likely act by binding metal ions in such a manner to allow the Fenton reaction, after which they scavenge ·OH. Such a mode of action is preferred by cells resulting in a safe degradation of H(2)O(2). On the other hand, the polysaccharides examined showed similar superoxide scavenging capacities. We propose that plants may employ different antioxidative characteristics of polysaccharides to regulate their redox status by modifying the composition of the cell wall.
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In vitro antioxidant activities of polysaccharides from endemic plants of Gabon
Jean Paul Akue
HAL (Le Centre pour la Communication Scientifique Directe), 2011
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ANTIOXIDANT AND IMMUNOSTIMULATING ACTIVITY OF POLYSACCHARIDES EXTRACTED FROM
Bernadeth Ticar
The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document and are linked to publications on ResearchGate, letting you access and read them immediately.
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Plant-Based Polysaccharides and their Health Functions
Food Science Publisher
Functional Food in Health and Disease, 2021
Plants are valuable source of polysaccharides that make a large portion of our daily diet. These are natural polymers that are essential to sustain life. They provide high-value nutrition and positively help the immune system and improve the digestive properties. They also help in the elimination of toxic by-products from the human body. Polysaccharides and human health are inextricably linked and intertwined. These are also important components of the cell wall that provides its strength and integrity. Due to their indispensable role in human health, it is very important to know the different modifications and loss of nutritional value during the processing of plant material. Nowadays, these plant-based polysaccharides are used for diverse applications including wound dressing, drug delivery, laxative, cosmetic and pharmaceutical preparations. As an emerging area of plant-based medicines to reduce the side effects of synthetic sources, these polysaccharides are used to enhance the immunogenic response against a specific antigen. This review envisages some important polysaccharides (e.g. mucilages and gums, glycosamine glycans and chitin/chitosan) and their medical, cosmetic, and pharmaceutical applications, with emphasis on the relationship between their structure and function. Keywords: Polysaccharides; Nutrition; Health Functions; Cosmetics; Vaccine; Nutraceuticals
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Chitosan gallate as a novel potential polysaccharide antioxidant: an EPR study
Suwabun Chirachanchai
Carbohydrate Research, 2010
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Extraction, Characterization, and Antioxidant Activity of Polysaccharides from Ajwa Seed and Flesh
Mariusz Jaremko
Separations, 2023
The date palm has been cultivated in dry and hot areas of the planet for much of human history. In the Kingdom of Saudi Arabia, dates are the main crop used as a source of food. Among several species of date fruits, the Ajwa AL-Madinah date is unique, growing only in Al-Madinah geographical region. The Ajwa date is used in traditional medicine due to its abundant active components and therapeutic properties. This study investigates the structural properties and the antioxidant effects of water-soluble polysaccharides extracted from Ajwa flesh and seed. The polysaccharides were isolated by two techniques including hot water and ultrasonic extraction. After isolation and partial purification, the physicochemical properties of four samples of polysaccharides extracted from flesh and seed were studied by several techniques including FTIR, solid-state NMR, elemental analysis, and mass spectrometry. Several radical scavenging experiments were combined to study the antioxidant activity of the polysaccharide compounds. FTIR and NMR results showed a structure typical of heterogeneous polysaccharides. Mass spectrometry revealed that the polysaccharide samples were composed mainly of mannose, glucose, galactose, xylose, arabinose, galacturonic acid, and fucose. In addition, the physicochemical properties and composition of polysaccharides extracted from flesh and seed were compared. The extracted polysaccharides showed antioxidant activity, with 2, 2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging, Fe chelating ability, hydroxyl free radical scavenging ability, and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging. These results highlight their potential to be a useful nutritional element or supplemental medication.
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Screening of Antioxidative and Antiproliferative Activities of Crude Polysaccharides Extracted from Six Different Plants
OMOWUMI ADEWALE
Applied sciences, 2024
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